FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Lymphocyte, neutrophil, platelets, restraint, stress, taurine
The aim of this study was to investigate the effects of taurine administration (100, 200 and 400 mg/kg) on haematological parameters in Wistar rats subjected to acute restraint stress (ARS) (1 hr/day for 14 days). Thirty adult Wistar rats were divided into five groups of six rats each; unstressed control group (USC) that received distilled water 1 ml/kg, restraint stressed control group (RSC) that received distilled water 1 ml/kg, restraint stressed group (RS) that received taurine 100 mg/kg, restraint stressed group (RS) that received taurine 200 mg/kg and restraint stressed group (RS) that received taurine 400 mg/kg. Taurine was administered once daily by oral gavage. At the end of the 14 days, the rats were sacrificed and blood sample was collected via intra-cardiac route; 2.5 ml blood was taken from each animal for blood analysis. Total white blood count (WBC), differential white blood cell count, platelet count, Packed cell volume (PCV), haemoglobin concentration (Hb), red blood cell count (RBC), erythrocyte indices, and erythrocyte osmotic fragility (EOF) test were determined. Results showed that, platelets count significantly (P < 0.05) increased at taurine 200 mg/kg. There was significant (P < 0.05) increase in WBC and neutrophil counts at taurine 400 mg/kg. However there was significant (P < 0.05) decreases in lymphocyte count in the taurine treated groups. The neutrophil/lymphocyte ratio showed no significant (P > 0.05) difference in the groups. In conclusion taurine at doses of 200 and 400 mg/kg significantly increased platelets and WBC counts respectively in restraint-stressed Wistar rats.
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